As we've touched on in previous posts, healthcare needs technology in order to advance it's capabilities and deliver on the staggering potential of what tech-enabled healthcare can achieve.
This broad statement can be refined a bit, though, to say that healthcare needs to adopt more technologically advanced tools within patient and provider workflows; even further, these tools need to rethink the way a provider administers or a patient receives care. They need to be easier to use than previous methods, they need to be efficient and save clinicians' time, and most importantly, new technology in healthcare has to make living a viably healthier life possible for more patients.
While sounding like a straightforward-enough directive, this is an incredibly tall task—healthcare is an expansive field, and often people don't realize how many use cases require specific therapeutic tools and devices. This variance across workflows makes forward progress difficult for the industry at large because adoption takes time, and even when it does happen, it may only affect one workflow within one vertical.
Redox is solving this rate-of-adoption problem, but in the mean time, digital health technologists have already developed a myriad new ways for patients to receive better care and live healthier lives. Already in use at health systems across the country, we looked into the top therapeutic device companies in America and are sharing their innovative new tools with you.
Autonomic Technologies — Mountain View, California: is a medical device company focused on the development and commercialization of innovative therapies for the treatment of autonomic disorders, particularly severe headache. The company’s initial product, the Pulsante® Microstimulator, is CE marked in Europe for the treatment of cluster headache.
Apollo Endosurgery — San Diego, California: Apollo Endosurgery is an interventional medical device company focused on revolutionizing minimally invasive surgery through its flexible endoscopic surgery platform and Lap-Band® product.
Vertos Medical — Aliso Viejo, California: Vertos Medical is committed to developing innovative, minimally invasive treatments for lumbar spinal stenosis (LSS). Its proprietary technologies include mild®, which offers a safe, outpatient, minimally invasive, fluoroscopically guided therapeutic LSS treatment that requires no general anesthesia, no implants, and no stitches.
Confluent Medical Technologies — Fremont, California: Confluent Medical Technologies is dedicated to taking projects from rapid prototype into high volume production, delivering world-class medical devices through innovative material science, engineering, and manufacturing. Their primary capabilities include: nitinol components, balloon expandable stents and balloon catheters, delivery systems, biomedical textiles, access kits, and guidewires.
Moximed — Hayward, California: Moximed Inc. is dedicated to improving the standard of care for patients with osteoarthritis, and is investigating therapies to treat a number of affected joints. The lead product, the KineSpring® Knee Implant System, is designed for patients with knee osteoarthritis.
SetPoint Medical — Santa Clarita, California: SetPoint Medical is developing novel bioelectronic medicine therapies to treat those who suffer from inflammatory diseases such as Crohn's Disease and rheumatoid arthritis. The company is developing a proprietary and innovative bioelectronic medicine platform consisting of a micro-regulator programmed via a unique prescription pad based interface.
Adavium Medical — Palo Alto, California: Adavium was formed with the intent to bring commercial sophistication to a highly fragmented market, partnering with some of the most innovative companies in the world, and developing and commercializing complementary high-quality, yet cost-effective, products that they develop on their own for the value-based – or “long tail” – segment of the market in Brazil and in other emerging markets.
ExThera Medical — Martinez, California: ExThera Medical Corporation is developing revolutionary medical devices that address unmet clinical needs for the treatment of bloodstream infections and pathogen-reduction in blood banking. Their focus is on therapeutic applications to treat drug-resistant and drug-susceptible bloodstream infections in high-risk patient populations, but also intends to develop a device that prophylactically safeguards banked human blood.
BioTheranostics — San Diego, California: Biotheranostics, Inc., is a leader in helping physicians improve the care of cancer patients, offering a suite of proprietary genomics-based molecular diagnostics that allow treatment to be tailored to individual patients.
Inari Medical — Aliso Viejo, California: Inari Medical is a medical device company pioneering devices for the interventional treatment of vascular thrombi and emboli.
Sommetrics — Vista, California: Sommetrics develops products and services aimed at enhancing health and well-being by improving sleep quality. The company’s proprietary technology targets disorders related to the narrowing of the airway during sleep, such as obstructive sleep apnea and chronic snoring. Sommetrics has an FDA-cleared and CE-marked acute care product, which addresses airway narrowing commonly caused by mild to moderate sedation.
Glaukos — San Clemente, California: Glaukos Corporation is an ophthalmic medical technology company focused on the development and commercialization of breakthrough products and procedures to transform the treatment of glaucoma, one of the world’s leading causes of blindness. Glaukos has pioneered Micro-Invasive Glaucoma Surgery, or MIGS, to revolutionize the traditional glaucoma treatment and management paradigm.
Dart Neuroscience — San Diego, California: Dart NeuroScience is discovering new technologies and developing new therapies to help maintain cognitive vitality throughout life. DNS's mission is to become the leading specialized pharmaceutical company for memory disorders by focusing on the discovery and development of innovative drugs with new mechanisms of action.
LoneStar Heart — Irvine, California: LoneStar Heart, Inc. is developing new therapies to preserve and restore adequate heart function in patients with Advanced Heart Failure (HF). The company’s lead product, Algisyl, is an alginate hydrogel that is implanted into the wall of the left ventricle to treat patients with dilated cardiomyopathy.
Imthera Medical — San Diego, California: ImThera Medical designs and manufactures a fully implantable medical device for the treatment of Obstructive Sleep Apnea (OSA): the THN Sleep Therapy. ImThera's sleep apnea implant delivers muscle tone to key tongue muscles during sleep, opening the upper airway and substantially reducing or eliminating OSA events.
Proteus Digital Health — Redwood City, California: Proteus is creating a new category of therapy: Digital Medicines. Digital Medicine therapy includes drugs that communicate when they’ve been taken, wearable sensors that capture physiologic response, applications that support patient self-care and physician decision making, and data analytics to serve the needs of doctors and health systems.
Prometheus Laboratories — San Diego, California: Prometheus Laboratories Inc. is committed to improving lives through the development and commercialization of novel pharmaceutical and diagnostic products that enable physicians to provide greater individualized patient care.
Outset Medical — San Jose, California: Outset is a pioneering medical technology company that always puts the patient before the machine. Their human-centered model is designed to dramatically improve not only the care experience – for patients, families, providers and physicians alike – but also cost-efficiencies for providers.
PulmonX — Redwood City, California: Pulmonx is focused on developing life-changing technologies that improve the lives of patients suffering from lung disease. Their first commercial products address emphysema, a form of COPD (chronic obstructive pulmonary disease) and the largest unmet medical need in Pulmonology.
Nevro — Menlo Park, California: Nevro is a global medical device company focused on providing innovative products that improve the quality of life of patients suffering from debilitating chronic pain. Nevro has developed and commercialized the Senza spinal cord stimulation (SCS) system, an evidence-based neuromodulation platform for the treatment of chronic pain.
Relievant Medsystems — Redwood City, California: Relievant Medsystems, Inc., a privately held medical device company pioneering the INTRACEPT therapy of nerve ablation within vertebral bodies for the treatment of chronic low back pain (CLBP).
RefleXion Medical — Hayward, California: Reflexion aims to transform cancer treatment and impact the lives of millions of patients around the world through the development of the first biology-guided radiotherapy (BgRT) system for solid tumor treatment.
Penumbra — Alameda, California: Penumbra designs, develops, manufactures and markets innovative devices and has a broad portfolio of products that addresses challenging medical conditions and significant clinical needs across two major markets, neuro and peripheral vascular.
Palo Alto Health Sciences — Danville, California: Palo Alto Health Sciences is a leader in innovative, clinically-proven, non-invasive, drug-free solutions for behavioral health conditions.Their first product, Freespira, is an FDA-cleared treatment for Panic Disorder (PD) and the symptoms of panic (including panic attacks) which clients use twice-daily at-home for one month under the supervision of a healthcare provider.
Cianna Medical — Aliso Viejo, California: Cianna Medical is committed to easing the burden of breast cancer on women and their families by developing unparalleled technologies to improve the treatment process for both patients and doctors. Their product, SAVI Brachytherapy, delivers targeted and individualized radiation treatment in less time, with less toxicity, giving more women the option to receive radiation treatment.
Element Science — San Francisco, California: Element Science develops life saving wearable solutions with user-centric design based on a rigorous approach to medical device development and the integration and application of data science and machine learning. Their first product aims to redefine treatment for sudden cardiac death, a disease that claims over 300,000 lives in the US every year.
eNeura Therapeutics — Sunnyvale, California: eNeura Therapeutics is pioneering the use of portable, non-invasive Transcranial Magnetic Stimulation (TMS) devices for treatment of migraines. Prescribed by physicians but designed for patient use, it is the first truly portable, convenient TMS product that will allow migraine patients to administer treatment as needed—at home, in the office, or on the go
CoolSystems — Alameda, California: CoolSystems is a medical device maker focused on treating post-surgical orthopedic sports injuries. The company operates primarily through its flagship product GameReady. The GameReady device essentially provides ice cold water and pressure to injured joints/body parts.
Axonics Modulation Technologies — Irvine, California: Axonics Modulation Technologies, Inc is a privately-held medical device company developing an innovative neuromodulation platform based on miniaturized rechargeable technology. The Axonics Sacral Neuromodulation System™ is the first CE-marked rechargeable SNM system designed to improve the life of patients suffering from Urinary and Fecal dysfunction.
C2 Therapeutics — Redwood City, California: C2 Therapeutics, Inc. develops ablation therapies to treat diseases of the gastrointestinal tract. C2 Therapeutics developed the C2 CryoBalloon® Ablation System for use as a cryosurgical tool in the field of general surgery, specifically for endoscopic applications, to include ablation of Barrett’s esophagus with dysplasia.
Aerin Medical — Santa Clara, California: Aerin Medical, Inc. develops devices and procedures to improve nasal breathing. Aerin’s treatments are specifically designed to address nasal congestions and obstruction in the Ear Nose & Throat (ENT) physician’s office, where they can be administered in minutes under the use of a local anesthetic and minimal prep time.
Avinger — Redwood City, California: Avinger designs, manufactures, and sells image-guided, catheter-based systems for the treatment of patients with peripheral artery disease (PAD). Their mission is to radically change the way vascular disease is treated through the introduction of products based on its lumivascular platform, the only intravascular image-guided system of therapeutic catheters available.
SynCardia Systems — Tucson, Arizona: SynCardia Systems manufactures the world's first and only FDA, Health Canada, and CE approved Total Artificial Heart. For people suffering from end-stage heart failure affecting both sides of the heart (biventricular failure), the SynCardia temporary Total Artificial Heart is used as a bridge to transplant, helping them survive until a matching donor heart becomes available.
Valley Respiratory Services — Mesa, Arizona: Valley Respiratory envisions a comprehensive approach to treatment of respiratory disorders by offering a range of respiratory equipment. Their mission is to provide the highest quality patient care by offering the best education, recommending the right equipment, and delivering an outstanding level of customer service to patients and referral sources.
CyMedica Orthopedics — Scottsdale, Arizona: CyMedica Orthopedics develops and commercializes innovative products that target muscle atrophy using its platform technology. That technology includes the first closed-loop power control system to provide patients comfortable yet aggressive treatment.
Ekos — Bothell, Washington: EKOS Corporation pioneered the development and the clinical application of ultrasound accelerated thrombolysis, introducing its first system for the treatment of vascular thrombosis in 2005.
Kona Medical — Bellevue, Washington: Kona Medical has developed an innovative and non-invasive therapy for the treatment of hypertension and other disorders. Their flagship product, the Surround Sound® Hypertension Therapy System, provides a one-time, non-invasive therapy for hypertension using ultrasound imaging to robotically guide the delivery of focused ultrasound energy for renal denervation (RDN).
Nativis — Seattle, Washington: Nativis is a clinical stage bioelectronics company developing non-invasive therapies for cancers and other serious diseases. At the interface of chemistry and physics, their proprietary Radio Frequency Energy (RFE) technology regulates defined bioactive targets by specific modulation of charge pathways.
Mirabilis Medica — Bothell, Washington: Mirabilis Medica focuses on the treatment of uterine fibroids that is a common problem for women. Its products include a non-invasive therapeutic solution for use by gynecologists that allows them to treat pathological tissue deep inside the body without incisions, punctures, or other damage to intervening tissue.
Calypso Medical Technologies — Seattle, Washington: Calypso Medical’s proprietary tumor localization system utilizes miniaturized implanted devices (BeaconÂ® electromagnetic transponders) to continuously, accurately and objectively track the location of tumors for improved accuracy and management of radiation therapy delivery. The technology is designed for body-wide cancers commonly treated with radiation therapy.
Surefire Medical — Westminster, Colorado: Surefire Medical develops innovative infusion systems for the Interventional Radiology and the Interventional Oncology markets. Surefire’s technology is designed to precisely deliver embolic agents through a unique microcatheter with an expandable tip, which collapses during forward flow to allow normal blood flow to carry therapy as close to the tumor as possible.
Terumo BCT — Lakewood, Colorado: Terumo BCT is a global leader in blood component, therapeutic apheresis and cellular technologies serving customers in more than 120 countries.
BackJoy Orthotics — Boulder, Colorado: BackJoy’s easy-to-use products and personal wellness initiatives help users naturally sit, stand and sleep better to produce positive, life-changing results.
SPR Therapeutics — Cleveland, Ohio: SPR Therapeutics is a medical device company commercializing pain treatments utilizing its proprietary peripheral nerve stimulation (PNS) products. They’ve developed a pipeline of neurostimulation pain therapies that will exploit the same physiologic mechanism of action, proprietary technology, and clinical approach.
Omni Orthopaedics — Canton, Ohio: OMNI Orthopaedics treats a full range of orthopaedic problems, and their board-certified orthopaedic surgeons keep current on the newest advances in orthopaedic care including computer-assisted surgery and minimally invasive procedures.
Neuros Medical — Willoughby, Ohio: Neuros Medical, a neurostimulation company, is focused on developing proprietary neurostimulation therapies for unmet needs to patients worldwide. Their patented platform technology, Nerve Block, is focused on elimination of chronic pain in a variety of applications including neuroma/residual limb pain, chronic post surgical pain, and chronic migraine.
Saluda Medical — Bloomington, Minnesota: Saluda Medical develops advanced and fully-implantable neuromodulation systems for the next generation of implantable stimulation devices. They are a cutting edge and progressive company at the forefront of spinal cord stimulation technologies for the management of chronic pain.
Minnetronix — St. Paul, Minnesota: Minnetronix is a medical technology and innovation company with deep expertise in electronic and electromechanical devices. Founded in 1996, they create new technologies and therapies that solve unmet clinical and business needs for patients and medical device companies.
Galil Medical — Arden Hills, Minnesota: Galil Medical is a global leader in delivering innovative cryoablation solutions addressing patient conditions across multiple physician specialties; treatment areas include conditions affecting bone, kidney, liver, lung and prostate, as well as targeted pain and nerve applications.
EnteroMedics — St. Paul, Minnesota: EnteroMedics developed vBloc® neurometabolic therapy, delivered by a pacemaker-like device called the Maestro® Rechargeable System, a first-in-class weight loss treatment for obesity and obesity related risk factors, such as high blood pressure or high cholesterol levels. vBloc Therapy is a non-anatomy altering or restricting and reversible therapy that allows patients to safely lose weight by helping patients feel less hungry, reduce the amount of food eaten at a meal, and feel full longer in between meals.
HistoSonics — Ann Arbor, Michigan: HistoSonics’ mission is to redefine cancer treatment with a non-invasive, highly precise, cost-effective method of tumor destruction called Robotically Assisted Sonic Therapy (RAST)(tm). This new modality in development – which is non-thermal and does not use radiation – has the potential to treat a broad range of cancers in an outpatient setting, without the incisions, punctures, nausea, pain, fatigue, scarring and long recovery times associated with existing methods of cancer treatment.
EndoStim — St. Louis, Missouri: EndoStim is a medical device company focused on the treatment of gastroesophageal reflux disease (GERD) through electrical stimulation of the lower esophageal sphincter. EndoStim’s innovative technology provides a solution addressing the root physiological cause of the disease, namely a weak or dysfunctional lower esophageal sphincter that allows for reflux into the esophagus.
ProNova Solutions — Maryville, Tennessee: ProNova Solutions meets the needs of cancer patients by making Proton Therapy accessible to a greater number of patients and physicians throughout the world. The fusion of state-of-the-art imaging, multi-axis precision positioning, superconducting magnet technology, and unprecedented closed loop treatment verification using Positron Emission Tomography brings ProNova customers clinical, operational, and financial benefits that will make major improvements in patient care, outcomes, and value.
TearScience — Morrisville, North Carolina: TearScience, a medical device company, pioneered technologies to vastly improve evaluation and treatment of meibomian gland dysfunction (MGD). LipiFlow uses Vectored Thermal Pulse™ (VTP) technology to precisely direct treatment from the inner-lid and has received clearance by the US Food and Drug Administration for use in patients with MGD.
CivaTech Oncology — Durham, North Carolina: CivaTech Oncology designs innovative products that bring meaningful improvements to low dose rate brachytherapy. The CivaString® and CivaSheet™ can substantially reduce procedure time, provide homogeneous dose distribution and minimize trauma. Customizable CivaTech products ensure that radiation oncologists can deliver individualized, targeted therapy to treat cancer.
Synecor — Chapel Hill, North Carolina: Synecor evolved from the confluence of several synergistic strategic relationships, initially in the field of interventional cardiology, but has expanded its field to include all medical specialties such as obesity, spine therapeutics, and more. Synecor was founded by Dr. Richard Stack after two decades of collaboration with leading cardiologists, clinician-inventors, and scientists from across the nation and as an outgrowth of close working relationships among corporate leaders in the medical device industry, and experts at Duke University.
Inova Labs — Austin, Texas: Inova Labs, Inc., founded in 2002, is a medical device company which develops and commercializes innovative products for patients with respiratory illness. Inova Labs is fully ISO 13485 certified utilizing state-of-the-art manufacturing systems and facilities. Their devices, LifeChoice Activox POCs and Activox DUO2, are revolutionizing oxygen therapy and patient freedom.
ProTom International — Flower Mound, Texas: ProTom International is a leading device manufacturer of proton therapy technology. Founded a decade ago, their mission is to transform cancer treatment by expanding the accessibility of proton therapy. Their Radiance 330® Proton Therapy System delivers vanguard proton therapy treatment with the precision of pencil-beam scanning and the power of integrated imaging.
Procyrion — Houston, Texas: Procyrion is developing the first catheter-deployed circulatory assist device intended for long-term use. The Procyrion device will be the first minimally invasive tool for cardiologists to treat over 1M NYHA Class III and early class IV heart failure (HF) patients in the US who have few therapeutic options.
Vapotherm — Exeter, New Hampshire: Vapotherm develops and manufactures innovative, comfortable, noninvasive technologies for respiratory support of patients with chronic or acute breathing disorders. Over 1 million patients have been successfully treated with Vapotherm high flow therapy.
Allurion Technologies — Natick, Massachusetts: Allurion Technologies is developing a medical device for weight loss that can be delivered and removed without surgery or endoscopy.
Thermedical — Waltham, Massachusetts: Thermedical was founded by Michael G. Curley, Ph.D., and Patrick S. Hamilton, Ph.D. Under multiple National Institutes of Health (NIH) Small Business Innovation Research (SBIR) Grants and a Massachusetts Life Sciences Center Small Business Matching Grant (SBMG) Award, Thermedical is developing thermal ablation systems to treat previously untreatable cancer and cardiac arrhythmias.
Tal Medical — Boston, Massachusetts: Tal Medical is a clinical stage neuroscience company developing non-invasive neurostimulation treatments for brain disorders. Their aim is to redefine the clinical practice of psychiatry and neurology by introducing safe, effective medical devices as standards of care, and their initial focus is on depression and sleep.
Mevion Medical Systems — Littleton, Massachusetts: Mevion Medical Systems is a leading provider of proton therapy systems for use in radiation treatment for cancer patients. The MEVION S250 Series is designed to deliver high-powered, efficient proton therapy treatments. Built upon the world’s only gantry-mounted proton accelerator and benefitting from Mevion’s patented direct beam technology, the MEVION S250 Series delivers on the therapeutic promise of proton therapy while enhancing beam quality, stability and uptime.
Intrinsic Therapeutics — Woburn, Massachusetts: Intrinsic Therapeutics is dedicated to the science of spinal care with a focused mission: To offer surgeons and patients better options for treating painful disc herniations that cause sciatica and low back pain for millions of people worldwide. Intrinsic Therapeutics’ mission is to offer surgeons and patients better options for treating disc herniations in the spine, as such injuries are responsible for the majority of low back pain and sciatica suffered by over 5 million people in the U.S. alone.
Arsenal Medical — Watertown, Massachusetts: Arsenal Medical is a private life sciences company that develops products based on Bioactive Composites to treat patients with complex clinical disorders. Bioactive Composites are combinations of materials that elicit targeted therapeutic effects.
Belmont Instrument — Billerica, Massachusetts: Belmont Instrument Corporation has developed some of the most sophisticated and reliable devices in fluid management and cardiac assist. Belmont offers The Belmont® Rapid Infuser, The Belmont® buddy™ series of close-to-the patient fluid and blood warmers and The Belmont® Hyperthermia Pump, an efficient and compact device for safe and effective hyperthermic lavage.
RenalGuard — Milford, Massachusetts: RenalGuard Solutions, Inc. is a medical technology company specializing in innovative technologies for the cardiac and vascular markets. Their newest product, RenalGuard, has been developed to help prevent the onset of contrast-induced nephropathy (CIN) in at-risk patients undergoing certain imaging procedures, and it’s already approved for sale in the EU for general fluid balancing.
MacuLogix — Middletown, Pennsylvania: MacuLogix is a pioneer in the early detection and tracking of retinal diseases and developed AdaptDx, the first practical measurement tool for dark adaptation. Based on significant technical advances, the AdaptDx provides doctors with an easy-to-use functional test similar to routine perimetry testing for glaucoma.
HeartSine — Newtown, Pennsylvania: HeartSine develops clinically advanced automated external defibrillators (AEDs) for the workplace, public access, and home markets. In fact, every AED in use today can trace its roots to technology envisioned and developed by HeartSine technologists.
TandemLife — Pittsburgh, Pennsylvania: TandemLife develops, manufactures, and markets innovative medical device products to provide Cardiologists and Cardiac Surgeons from around the world with unique solutions for patients requiring circulatory support. The FDA-cleared TandemHeartÂ® System delivers extracorporeal circulatory support in just minutes, not hours.
Ebb Therapeutics — Pittsburgh, Pennsylvania: Sleep is essential and Ebb Therapeutics is working tirelessly to provide a clinically-proven, FDA-cleared device for the treatment of insomnia that is safe and effective for use every night, without side effects.
ALung Technologies — Pittsburgh, Pennsylvania: ALung Technologies has developed the Hemolung Respiratory Assist System (RAS), a dialysis-like alternative or supplement to mechanical ventilation. The Hemolung RAS provides Respiratory Dialysis, a simple, less invasive form of extracorporeal CO2 removal. Applications of the device include preventing intubation in acute exacerbation of chronic obstructive pulmonary disease (COPD) and enabling ultra-protective ventilation in acute respiratory distress syndrome (ARDS).
Link Medicine — Baltimore, Maryland: Link Medicine is working on novel approaches to create disease-modifying therapies for a range of neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's disease and other conditions. Current therapies provide at best only symptomatic relief and are limited in their effectiveness and duration. New therapies are desperately needed, and successful development of a disease-modifying approach could have a major impact on human health and the cost of treatment.
Mederi Therapeutics — Greenwich, Connecticut: Mederi Therapeutics manufactures and markets innovative medical devices that deliver radiofrequency energy to treat disease states affecting the human digestive system. All Mederi therapies are outpatient, minimally invasive, and promote rapid recovery.
electroCore — Morris Plains, New Jersey: electroCore is, a US based bioelectronic medicine healthcare company, which is developing a range of non-invasive Vagus Nerve Stimulation (nVNS) patient administered therapies for the treatment of multiple conditions in neurology, psychiatry, gastroenterology and other fields.
Their initial focus is on primary headache (migraine and cluster headache), with trials continuing in epilepsy, gastric motility disorders, depression and anxiety.
AposTherapy — New York City, New York: Apos Medical was founded by medical doctors coming from the fields of Orthopedic Surgery and Sports Medicine following 10 years of research. The company successfully developed and commercialized AposTherapy, an innovative medical technology with applications in orthopaedics, neurology and paediatrics, with their current focus being knee osteoarthritis (OA) and other conditions within orthopaedics.
There you have it, the top therapeutics companies in America. If you need more about digital health companies and have already checked out "70 Companies Driving the Future of Healthcare Technology", you're in luck—we published a guide on the 48 AI companies disrupting healthcare that you can read here.
Most importantly, if you know of any companies who should be featured on this list, please let us know in the comments. We're all about evangelizing innovation and would be happy to include them here.